I am trying to achieve the kind of design as you see in the the following image:

As you can see some of the elements go all the way trough to the sides which makes it quiet complex.
Would it to be possible to create this in a kind of fluid responsive design where all elements scale when window scales or will I have to check and fix on all different sizes with a design like this?
I don't have much experience with responsive webdesign, suggestions are very welcome!
For those interested in the actual design:

